Kynurenic

- A high reading of this by-product of the breakdown of the amino acid tryptophan is consistent with a vitamin B6 deficiency, possible inflammatory processes, interferon-gamma stimulated macrophages or excessive tryptophan supplementation (not 5-HTP).

- Abnormally high levels can cause and increase in pain sensations and may, in multiple sclerosis patients, be a marker for an exacerbation period.

- Vitamin B6 deficiency may also result in elevated concentrations of homocysteine in blood, which leads to increased risk of heart disease.

- High levels of Kynurenic Acid can have direct effects on brain function in addition to showing a need for vitamin B6.

- High values in individuals with the yeast overgrowth syndrome may be due to yeast interference.

Research shows that kynurenic acid is low with a low protein diet and in autism spectrum disorder. 

Low kynurenic acid is implicated in depression, headaches, bipolar disorder, and Alzheimer’s disease.

Kynurenic Acid is product of the metabolism of L-Tryptophan and appears in urine in Vitamin B6 deficiencies. Your body needs vitamin B6 (pyridoxine) to utilize amino acids derived from dietary protein.