Isocyanates are a family of highly reactive, low molecular weight chemicals.
They are widely used in the manufacture of:
- foams,
- fibers,
- paints,
- varnishes and elastomers,
and are increasingly used in:
- insulation materials,
- car seats,
- surface coatings,
- furniture,
- foam mattresses,
- under-carpet padding,
- packaging materials,
- shoes,
- laminated fabrics, and adhesives,
- auto body repair,
- and the automobile industry.
Many spray-on polyurethane products contain isocyanates and are used privately and commercially to protect cement, wood, fiberglass, steel and aluminum, and for the protective coatings for truck beds, trailers, boats, foundations, and decks.
Occupational exposure to toluene diisocyanate (TDI) and other isocyanates can cause irritation of the mucous membranes, eyes, upper respiratory tract, and skin.
In a study of workers exposed to diisocyanates, IgG antibodies were somewhat more prevalent than IgE; IgG antibodies were detected in 24% of symptomatic workers and 17% of asymptomatic workers.
In a study on apprentice car-painters, a small proportion showed increases in hexamethylene diisocyanates-specific IgG and IgE after a few months of exposure. Furthermore, increases in specific IgG and IgG4 appear to have a protective effect on the incidence of work-related lower and upper respiratory symptoms, respectively. These antibodies can remain for years after removal of the chemical from the
patient’s environment.
One study on occupational exposure of TDI showed that serum levels of specific IgG antibodies were significantly higher in subjects showing a positive response in a TDIbronchoprovocation test (46%) compared with subjects exhibiting a negative TDI-bronchoprovocation test response (7.7%).
In a subsequent study, patients with TDI-occupational asthma with high serum IgG to tissue transglutaminase (tTG) had significantly lower methacholine PC20 values; thus TDI exposure may increase tTG activity via reactive oxygen species (ROS) production, leading to persistent airway inflammation in these patients. The detection of serum specific IgG is helpful for diagnosing isocyanate-induced asthma in that the test can be used to document exposure and monitor subclinical conditions.
Quick List Sources of Isocyanate:
- Polyurethane foams, carpet padding
- Pesticides
- Paints
- Automobiles
- Protective coatings on cement, wood, fiberglass, steel, aluminum, truck beds, decks, boats, trailers.
- Adhesives Insulation
- Plastics
References:
- Orloff KG, Batts-Osborne D, Kilgus T, et al. Antibodies to toluene diisocyanate in an environmentally exposed population. Environ Health Perspect, 1998; 106(10):665-666.
- Dragos M, Jones M, Malo JL, et al. Specific antibodies to diisocyanate and work-related respiratory symptoms in apprentice car-painters. Occup Environ Med, 2009; 66(4):227-234.
- Park HS, Lee SK, Lee YM, et al. Longitudinal study of specific antibodies to toluene diisocyanate (TDI)-human serum albumen (HSA) conjugate in patients with TDI-induced asthma. Korean J Intern Med, 2002; 17(4):249-251.
- Hur G-Y, Choi SJ, Shin SY, et al. Update on the pathogenic mechanisms of isocyanate-induced asthma. World Allergy Org J, 2008; 1(1):15-18.
- Hur G-Y, Kim SH, Park SM, et al. Tissue transglutaminase can be involved in airway inflammation of toluene diisocyanate-induced occupational asthma. J Clin Immunol, 2009; 29(6):786-794.
- Palikhe NS, Kim JH, Park HS. Biomarkers predicting isocyanate-induced asthma. Allergy Asthma Immunol Res, 2011; 3(1):21-26.
Keeping track of your medical data and laboratory results while understanding what they mean empowers positive health outcomes.
Keeping track of your medical data and lab results while understanding what they mean empowers positive health outcomes.
Save 10% off any plan with promo-code:
HEALTH10
Persons with antibodies to Isocyanate bound to human protein in serum should avoid exposure to the substance, with special attention taken to clean up the home and work environments.
The detection of antibodies to Isocyanate bound to human protein in serum indicates a breakdown in immunological tolerance and induction of chemical intolerance. Isocyanate or its metabolites can bind to human tissue proteins and form neo-antigens. These new antigens are comprised of the haptenic chemical plus the tissue antigen. The formation of neo-antigens initiates an immune response, which may result in antibody production against the chemical and the human tissue. Continued exposure to the chemical and the subsequent production of antibodies against various tissue antigens, may result in autoimmune reactivity.
Sign up
Sign up now and create your account. Use code HEALTH10 for a 10% discount on any plan. Don't miss out!
Organize
Bring all results from any laboratories to your account. You can enter your tests yourself, or we'll be happy to organize your files—whether in PDF, JPEG, CSV, or even screenshots.
Learn and improve
Once your information is stored in your account, dive into a wealth of insights about your results. If you have any more questions, we are here to answer them.
Guiding our user for 10 years to promptly understand, track, and act on their laboratory results.
$15/month
for personal lab results
Cancel your subscription at any time.
$250/once
full premium version
$45/month
track your clients’ labs
Cancel your subscription at any time.
Guiding our user for 10 years to promptly understand, track, and act on their laboratory results.
Personal plans
track personal results
Professional Plan
track multiple client's results
$15/month
for personal lab results
$250/once
own it for life
$45/month
for health professionals
Complete Plan
Unlimited Plan
$15 per month
$250 full version
Are you a health professional?
Level up your lab report analysis with our Pro plan, built for health practitioners like you.
Health Business Account
$45/month
Cancel your subscription at any time.
Unlock additional Pro plans when you sign up.
Unlock Your Health Journey with Healthmatters.io! Ever wished for a one-stop digital health haven for all your lab tests? Look no further! Healthmatters.io is your personalized health dashboard, bringing together test reports from any lab. Say goodbye to scattered results—organize and centralize your lab data effortlessly. Dive into the details of each biomarker and gain insights into the meaning behind your medical test data.
Join the community of thousands who've transformed the way they understand their lab results. Experience the joy of having all your lab data neatly organized, regardless of where or when the tests were done.
For our professional users, Healthmatters.io is a game-changer. Revel in the intuitive tools that not only streamline analysis but also save valuable time when delving into your client's lab report history. It's not just a dashboard; it's your gateway to a smarter, more informed health journey!
Healthmatters.io personal account provides in-depth research on 4000+ biomarkers, including information and suggestions for test panels such as, but not limited to:
You can combine all test reports inside your Healthmatters account and keep them in one place. It gives you an excellent overview of all your health data. Once you retest, you can add new results and compare them.
If you are still determining whether Healthmatters support your lab results, the rule is that if you can test it, you can upload it to Healthmatters.
While we do talk about popular labs, we welcome reports from lots of other places too. It's as simple as this: if you can get a test done, you can upload it to Healthmatters. We can interpret results from any lab out there. If laboratories can analyze it, we can interpret it.
Still on the hunt for a specific biomarker? Just tell us, and we'll add it to our database. Anything from blood, urine, saliva, or stool can be uploaded, understood, and tracked with your Healthmatters account!
There are two ways to add your test reports to your healthmatters.io account. One option is to input the data using the data entry forms. The other method is to utilize our "Data entry service."
Our data entry forms offer an easy, fast, and free way for you to input the reports yourself. Self-entry allows you to add an unlimited number of reports at no cost. We make the self-entry process user-friendly, providing dozens of templates that pre-populate the most popular laboratory panels and offering instant feedback on entered values.
For those who prefer assistance, we offer a "Data entry service" to help you input your data. Simply attach an image or file of your lab test results, and a qualified team member from our data entry team will add the results for you. We support various file types, including PDFs, JPGs, or Excel. This service is particularly useful if you have many reports to upload or if you're too busy to handle the data entry yourself.
Our special data entry service makes it easy to add your results to your private dashboard. Just attach an image or a file of your lab test results, and our skilled data entry team will do the work for you. It's all done by humans, ensuring that your data is entered accurately and with personal care for each client.
Depending on your account, the data entry service can be included for free or come at an additional cost of $15 per report.
For users on the Complete monthly plan, the first report is entered free of charge, and each additional report incurs a fee of $15.
Unlimited account holders enjoy the entry of ten reports without charge. Subsequent reports are subject to a $15 fee per report.
Additionally, users on the Complete plan can upgrade to a yearly subscription from the account settings. The annual subscription includes a data entry service for five reports.
The Unlimited plan is a one-time purchase for $250, and it covers your account for a lifetime with no additional payments.
For the Complete plan, the cost is $15 per month. You have the flexibility to cancel it anytime through your account settings, ensuring no further payments. To avoid charges, remember to cancel at least a day before the renewal date. Once canceled, the subscription remains active until the end of the current billing cycle.
Additionally, you can upgrade to the yearly Advanced plan from within your account. The annual cost is $79, and it comes with a data entry service for five reports.
You can always upgrade to a lifetime version with a prorated price from a monthly or yearly subscription.
Simply log in and navigate to your account settings to cancel your subscription. Scroll down to locate the 'Cancel' button at the bottom of the page. Ensure you cancel at least one day before the renewal date to prevent any charges. Once cancellation is requested, the subscription remains active until the conclusion of the current billing cycle.
Unlocking the insights from your lab tests has never been this intuitive! We've crafted multiple ways for you to navigate your data, whether you're glancing at a single report or delving into a treasure trove of testing data.
1. Graph View:Dive into a visual journey with our biomarker graphs, showcasing over 40 data points. Combining years of results unveils trends, empowering you to make informed decisions. Our visualization tools make it a breeze to compare and understand changes over time, even if your results are from different labs. A search function and filters simplify the exploration of extensive data, allowing you to focus on what needs attention.
2. All Tests ViewGet a quick grasp of your test reports in minutes! Explore neatly organized reports on a timeline, highlighting crucial details like dates, critical results, and lab/panel names. Each report opens up to reveal in-depth descriptions and additional recommendations for each biomarker. The history of previous results is just a click away, and you can download a comprehensive report for deeper insights. Color-coded and user-friendly, it's designed for easy reading, understanding, and navigation.
3. Table View:For a holistic view of all biomarkers side by side, our table view is your go-to. Results are neatly displayed in a categorized and dated table, ideal for those with an extensive test history. Utilize sorting, filters, and color-coding to enhance your analysis and gain extra insights.
Experience the power of clear, organized data visualization with Healthmatters.io — your key to understanding and taking charge of your health journey!
Yes, you can download information from your account. We can compile your labs into a CSV file. To download all your labs, you can go to Account Settings, and at the bottom of the page, you will find a link to download your information.
Yes, you can print your report. To do so, navigate to "All tests" and open the report you wish to print. You'll find a print button in the right corner of the report. Click on it, and your browser's print window will open. If you prefer to print in a bigger typeface, adjust the scale using the print window settings.
A personal account is all about keeping your own lab test results in check. It's just for you and your personal use.
The professional or business account is designed for health professionals who wish to track and organize their clients' laboratory results.
To learn more about Healthmatters Pro, please refer to the professional page.
At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.
Aflatoxins IgG+IgA, Aflatoxins IgM, Benzene Ring Compounds IgG+IgA, Benzene Ring Compounds IgM, Bisphenol A IgG+IgA, Bisphenol A IgM, BPA Binding Protein IgG+IgA, BPA Binding Protein IgM, Formaldehyde and Glutaraldehyde IgG+IgA, Formaldehyde and Glutaraldehyde IgM, Isocyanate IgG+IgA, Isocyanate IgM, Mercury Compounds IgG+IgA, Mercury Compounds IgM, Mixed Heavy Metals IgG+IgA, Mixed Heavy Metals IgM, Parabens IgG+IgA, Parabens IgM, Tetrabromobisphenol A IgG+IgA, Tetrabromobisphenol A IgM, Tetrachloroethylene IgG+IgA, Tetrachloroethylene IgM, Trimellitic and Phthalic Anhydrides IgG+IgA, Trimellitic and Phthalic Anhydrides IgM
