Interleukin-10 is an important suppressor of immune responses.
In vitro studies indicate that Interleukin-10 directly inhibits IL-2 and IL-5 production by TH1 and TH2 cells. Interleukin-10 acts as an immunosuppressor of antigen presenting cells (APC). Interleukin-10 suppresses epidermal Langerhans cell APC function, monocyte chemokines expression, and the bactericidal responses of macrophages. A number of studies suggest that IL-10 plays a role in controlling inflammation, autoimmunity, and angiogenesis.
References:
- Ding UZ, Fu S, Zamarin D, et al. Interleukin-10. In: Thomson AW, Lotze MT eds. Cytokine Handbook. 4th ed, vol 1. London, UK, and San Diego, Calif: Academic Press, Elsevier Science;2003:603-625.
- Mosser DM, Zhang X. Interleukin-10: New perspectives on an old cytokine. Immunol Rev. 2008 Dec; 226:205-218. PubMed 19161426
- Hedrich CM, Bream JH. Cell type-specific regulation of IL-10 expression In inflammation and disease. Immunol Res. 2010 Jul; 47(1-3):185-206. PubMed 20087682
- Iyer SS, Cheng G. Role of interleukin 10 transcriptional regulation in inflammation and autoimmune disease. Crit Rev Immunol. 2012;32(1):23-63. doi:10.1615/critrevimmunol.v32.i1.30
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Interleukin 10 (IL-10) is a cytokine with potent anti-inflammatory properties that plays a central role in limiting host immune response to pathogens, thereby preventing damage to the host and maintaining normal tissue homeostasis. Dysregulation of IL-10 is associated with enhanced immunopathology in response to infection as well as increased risk for development of many autoimmune diseases.
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CCL3 (MIP-1alpha), CCL4 (MIP-1beta), CCL5 (RANTES), Gamma interferon (IFN-gamma), Granulocyte and Monocyte CSF (GM-CSF), Interleukin-10 (IL-10), Interleukin-13 (IL-13), Interleukin-2 (IL-2), Interleukin-4 (IL-4), Interleukin-6 (IL-6), Interleukin-8 (IL-8 o CXCL8), Ligando CD40 (sCD40L), Tumor necrosis factor alpha (TNF-alpha), Vascular Endothelial Growth Factor (VEGF)
