The health implications of Glutathione S-Transferase (GST) are significant, as GST is crucial for Phase II detoxification of xenobiotics, carcinogens, and oxidative stress products. GSTM1, a specific variant of GST, is primarily located in the liver. The GSTM1 gene can be either present or absent (null). When at least one copy of the gene is present, it is classified as present; when both copies are absent, it is classified as absent. Polymorphisms in Glutathione S-Transferase are linked to a reduced ability to detoxify a wide range of substances, leading to increased oxidative stress and a higher risk of chronic diseases. This decreased detoxification capacity can impair the body's ability to handle environmental toxins, potentially resulting in long-term health consequences.
GSTM1
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