Cortisol Awakening Response + DHEA (Saliva)

Dehydroepiandrosterone (DHEA) Saliva

Optimal Result: 137 - 336 pg/mL.

The normal DHEA concentration alters significantly with age, gender and time of the day. During the day, DHEA values have the highest level in the morning and decrease over the day to the lowest level during night time. This pattern is somewhat similar to Cortisol. For this reason clear indication about the reference values is of utmost importance.

  Morning Evening
  Age n 5%-95% percentile Median 5%-95% percentile Median
[pg/mL] [pg/mL] [pg/mL] [pg/mL]

Females

14-39 39 101 - 687 277 46 - 406 130
40-85 31 68 - 397 241 39 - 198 92
14-85 (total) 70 80 - 641 252 38 - 368 110

Males

16-39 45 117 - 747 363 84 - 457 162
40-76 25 58 - 480 264 48 - 262 107
16-76 (total) 70 65 - 737 327 53 - 440

141

References: 

Measuring DHEA-S in saliva: time of day differences and positive correlations between two different types of collection methods [L]

 

What does it mean if your Dehydroepiandrosterone (DHEA) Saliva result is too low?

Lower levels of DHEA are seen with advancing age and have been associated with:

- immune dysregulation

- cardiovascular disease

- arthritis

- osteoporosis

- insomnia 

- declining cognition

- depression

- fatigue

- and decreased libido

General recommendations include overall control of the cortisol response, HPA axis support using nutrition, adaptogens, and behavioral modification.

What does it mean if your Dehydroepiandrosterone (DHEA) Saliva result is too high?

Elevated levels of DHEA may reflect endogenous exposure and supplementation.

Other considerations include Polycystic Ovarian Syndrome (PCOS,) adrenal hyperplasia and adrenal tumors.

General recommendations include overall control of the cortisol response, HPA axis support using nutrition, adaptogens, and behavioral modification.

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