Cortisone (E)

Urine

Optimal Result: 39 - 143 ug/g Creatinine.

Balance Hormone Profile (Dried Urine) Meridian Valley Lab

From Healthmatters.io Team

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What is Cortisone (E)?

Cortisone (also noted as E in laboratory reports) is an inactive metabolite of cortisol, the body’s main stress hormone. It is produced in the adrenal glands and serves as part of the body’s natural stress response system.

In the body, cortisone and cortisol are interconvertible—an enzyme system (11b-hydroxysteroid dehydrogenase types 1 and 2) constantly transforms cortisone into cortisol and vice versa, depending on the body’s needs.

By measuring urinary cortisone as part of the DU Balance Hormone Profile, clinicians can evaluate adrenal gland activity, stress response balance, and cortisol metabolism over time.

Why is Cortisone important?

Cortisone acts as a buffer and reservoir for cortisol, helping to regulate stress hormone availability. The cortisol–cortisone balance offers valuable insight into how your body:

Handles chronic stress
Converts and clears stress hormones
Maintains inflammation control and immune balance
Supports blood sugar regulation and energy levels

Understanding cortisone levels helps determine whether your adrenal system is overactive, underactive, or imbalanced in its stress hormone conversion.

Key takeaway

Cortisone (E) provides a snapshot of how your body metabolizes and balances cortisol, your primary stress hormone. Together, cortisol and cortisone levels reveal how well your adrenal system adapts to daily stress demands.

A balanced cortisone level indicates healthy stress hormone regulation, while persistent highs or lows may signal the need for adrenal support or stress management strategies.

Monitoring cortisone alongside other hormones on the DU Balance Hormone Profile—like cortisol, DHEA, and testosterone—offers a deeper understanding of your overall endocrine and stress resilience.

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What does it mean if your Cortisone (E) result is too high?

When Cortisone is elevated

High cortisone levels often reflect increased adrenal output or heightened cortisol metabolism—suggesting the body is working hard to adapt to ongoing stress.

Possible causes:

Chronic emotional or physical stress
Overactive adrenal function (hypercortisolism)
Inflammation or immune activation
Excess caffeine or stimulant use
High-intensity exercise without recovery
Corticosteroid medication use

Possible symptoms:

Trouble sleeping or staying asleep
Anxiety or restlessness
Weight gain (especially abdominal)
Sugar cravings
High blood pressure
Lowered immune resilience

Supportive measures:

Prioritize rest, relaxation, and recovery
Reduce caffeine and alcohol
Support adrenal balance with B-vitamins, magnesium, and adaptogenic herbs (ashwagandha, rhodiola)
Ensure adequate nutrition and hydration

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What does it mean if your Cortisone (E) result is too low?

When Cortisone is low

Low cortisone levels may indicate reduced cortisol production, sluggish adrenal activity, or impaired conversion between cortisol and cortisone.

Possible causes:

Adrenal fatigue or insufficiency
Chronic stress exhaustion (late-stage burnout)
Low pituitary (ACTH) stimulation
Anti-inflammatory or steroid medication suppression
Chronic illness, infection, or nutrient deficiencies

Possible symptoms:

Fatigue and low motivation
Brain fog and poor concentration
Low blood pressure or dizziness
Sugar or salt cravings
Feeling overwhelmed or easily stressed

Supportive measures:

Ensure consistent sleep and stress management practices
Eat regular, balanced meals with protein and complex carbs
Support adrenal recovery with vitamin C, B5, and electrolytes
Address underlying causes with your healthcare provider

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Cortisone (E)

What is Cortisone (E)?

Why is Cortisone important?

Key takeaway

All Your Lab Results. One Simple Dashboard.

What does it mean if your Cortisone (E) result is too high?

When Cortisone is elevated

All Your Lab Results. One Simple Dashboard.

Import, Track, and Share Your Lab Results Easily

Import, Track, and Share Your Lab Results

What does it mean if your Cortisone (E) result is too low?

When Cortisone is low

Article Review & Sources

Bring All Your Lab Results Together — In One Place

Gather Your Lab History — and Finally Make Sense of It

Finally, Your Lab Results Organized and Clear

Advanced Plan

Unlimited Account

Pro Monthly

What's included in a Healthmatters membership

Import Lab Results from Any Source

See Your Health Timeline

Understand What Your Results Mean

Enter Your Lab Reports Yourself — Always Free Enter Your Lab Reports — Always Free

Visualize Your Results

Export Your Complete Lab History in a Single File Export Your Complete Lab History

Comprehensive Data Entry Service for Your Reports Data Entry Service for Your Reports

Securely Share With Anyone You Trust

Let Your Lab Results Tell the Full Story

Once your results are in one place, see the bigger picture — track trends over time, compare data side by side, export your full history, and share securely with anyone you trust.

Bring all your results together to compare, track progress, export your history, and share securely.

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All Your Lab Results.
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