Cortisone (E)

When Cortisone is elevated

High cortisone levels often reflect increased adrenal output or heightened cortisol metabolism—suggesting the body is working hard to adapt to ongoing stress.

Possible causes:

• Chronic emotional or physical stress

• Overactive adrenal function (hypercortisolism)

• Inflammation or immune activation

• Excess caffeine or stimulant use

• High-intensity exercise without recovery

• Corticosteroid medication use

Possible symptoms:

• Trouble sleeping or staying asleep

• Anxiety or restlessness

• Weight gain (especially abdominal)

• Sugar cravings

• High blood pressure

• Lowered immune resilience

Supportive measures:

• Prioritize rest, relaxation, and recovery

• Reduce caffeine and alcohol

• Support adrenal balance with B-vitamins, magnesium, and adaptogenic herbs (ashwagandha, rhodiola)

• Ensure adequate nutrition and hydration

When Cortisone is low

Low cortisone levels may indicate reduced cortisol production, sluggish adrenal activity, or impaired conversion between cortisol and cortisone.

Possible causes:

• Adrenal fatigue or insufficiency

• Chronic stress exhaustion (late-stage burnout)

• Low pituitary (ACTH) stimulation

• Anti-inflammatory or steroid medication suppression

• Chronic illness, infection, or nutrient deficiencies

Possible symptoms:

• Fatigue and low motivation

• Brain fog and poor concentration

• Low blood pressure or dizziness

• Sugar or salt cravings

• Feeling overwhelmed or easily stressed

Supportive measures:

• Ensure consistent sleep and stress management practices

• Eat regular, balanced meals with protein and complex carbs

• Support adrenal recovery with vitamin C, B5, and electrolytes

• Address underlying causes with your healthcare provider

Cortisone (also noted as E in laboratory reports) is an inactive metabolite of cortisol, the body’s main stress hormone. It is produced in the adrenal glands and serves as part of the body’s natural stress response system.

In the body, cortisone and cortisol are interconvertible—an enzyme system (11b-hydroxysteroid dehydrogenase types 1 and 2) constantly transforms cortisone into cortisol and vice versa, depending on the body’s needs.

By measuring urinary cortisone as part of the DU Balance Hormone Profile, clinicians can evaluate adrenal gland activity, stress response balance, and cortisol metabolism over time.