The biomarker CD3+/CD4-/CD8- identifies a unique subset of T lymphocytes that express the CD3 surface protein but lack both CD4 and CD8 co-receptors. These cells are often referred to as double-negative T cells (DN T cells) due to their absence of CD4 and CD8 expression. DN T cells represent a small fraction of the total T cell population in peripheral blood, typically accounting for less than 5% of T cells. Despite their rarity, these cells play important roles in immune regulation and have been implicated in various autoimmune diseases, transplant rejection, and cancer immunology. DN T cells can exhibit both immunosuppressive and pro-inflammatory functions, depending on the context. They are capable of producing cytokines and can have cytotoxic activity. The CD3+/CD4-/CD8- phenotype is typically assessed using flow cytometry, which allows for precise identification and quantification of this cell population. Alterations in the frequency or function of DN T cells may serve as indicators of immune dysregulation or specific disease states.f
What does it mean if your CD3+/CD4-/CD8- (%) result is too high?
Elevated levels of CD3+/CD4-/CD8- T cells, also known as double-negative T cells (DN T cells), can signify several conditions:
- Autoimmune disorders: Increased levels of DN T cells have been associated with various autoimmune diseases, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis.
- Immune dysregulation: Elevated DN T cell counts may indicate an imbalance in the immune system, as these cells can have both immunosuppressive and pro-inflammatory functions.
- Chronic infections: Some chronic viral infections may lead to an increase in DN T cells as part of the immune response.
- Certain cancers: Elevated levels of DN T cells have been observed in some types of lymphomas and leukemias.
- Transplant rejection: In organ transplant recipients, higher levels of DN T cells may be associated with an increased risk of graft rejection.
- Immunodeficiency disorders: Paradoxically, some primary immunodeficiency disorders can present with elevated DN T cell counts.
- Aging: There is evidence that DN T cell populations may increase with age, potentially contributing to age-related immune changes.
It's important to note that the significance of elevated CD3+/CD4-/CD8- T cells can vary depending on the specific clinical context and should be interpreted in conjunction with other immunological markers and clinical findings. While these cells represent a small fraction of the total T cell population in peripheral blood (typically less than 5%), changes in their levels may provide valuable insights into immune function and potential underlying conditions.
All Your Lab Results.
One Simple Dashboard.
Import, Track, and Share Your Lab Results Easily
Import, Track, and Share Your Lab Results
Import lab results from multiple providers, track changes over time, customize your reference ranges, and get clear explanations for each result. Everything is stored securely, exportable in one organized file, and shareable with your doctor—or anyone you choose.
Cancel or upgrade anytime
Laboratories
Bring All Your Lab Results Together — In One Place
We accept reports from any lab, so you can easily collect and organize all your health information in one secure spot.
Pricing Table
Gather Your Lab History — and Finally Make Sense of It
Finally, Your Lab Results Organized and Clear
Personal plans
$79/ year
Advanced Plan
Access your lab reports, explanations, and tracking tools.
- Import lab results from any provider
- Track all results with visual tools
- Customize your reference ranges
- Export your full lab history anytime
- Share results securely with anyone
- Receive 5 reports entered for you
- Cancel or upgrade anytime
$250/ once
Unlimited Account
Pay once, access everything—no monthly fees, no limits.
- Import lab results from any provider
- Track all results with visual tools
- Customize your reference ranges
- Export your full lab history anytime
- Share results securely with anyone
- Receive 10 reports entered for you
- No subscriptions. No extra fees.
$45/ month
Pro Monthly
Designed for professionals managing their clients' lab reports
- Import lab results from any provider
- Track lab results for multiple clients
- Customize reference ranges per client
- Export lab histories and reports
- Begin with first report entered by us
- Cancel or upgrade anytime
About membership
What's included in a Healthmatters membership
Import Lab Results from Any Source
See Your Health Timeline
Understand What Your Results Mean
Visualize Your Results
Data Entry Service for Your Reports
Securely Share With Anyone You Trust
Let Your Lab Results Tell the Full Story
Once your results are in one place, see the bigger picture — track trends over time, compare data side by side, export your full history, and share securely with anyone you trust.
Bring all your results together to compare, track progress, export your history, and share securely.
What Healthmatters Members Are Saying
Frequently asked questions
Healthmatters is a personal health dashboard that helps you organize and understand your lab results. It collects and displays your medical test data from any lab in one secure, easy-to-use platform.
- Individuals who want to track and understand their health over time.
- Health professionals, such as doctors, nutritionists, and wellness coaches, need to manage and interpret lab data for their clients.
With a Healthmatters account, you can:
- Upload lab reports from any lab
- View your data in interactive graphs, tables, and timelines
- Track trends and monitor changes over time
- Customize your reference ranges
- Export and share your full lab history
- Access your results anytime, from any device
Professionals can also analyze client data more efficiently and save time managing lab reports.
Healthmatters.io personal account provides in-depth research on 10000+ biomarkers, including information and suggestions for test panels such as, but not limited to:
- The GI Effects® Comprehensive Stool Profile,
- GI-MAP,
- The NutrEval FMV®,
- The ION Profile,
- Amino Acids Profile,
- Dried Urine Test for Comprehensive Hormones (DUTCH),
- Organic Acids Test,
- Organix Comprehensive Profile,
- Toxic Metals,
- Complete Blood Count (CBC),
- Metabolic panel,
- Thyroid panel,
- Lipid Panel,
- Urinalysis,
- And many, many more.
You can combine all test reports inside your Healthmatters account and keep them in one place. It gives you an excellent overview of all your health data. Once you retest, you can add new results and compare them.
If you are still determining whether Healthmatters support your lab results, the rule is that if you can test it, you can upload it to Healthmatters.
We implement proven measures to keep your data safe.
At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. Our internal code of conduct adds additional privacy protection. All data is backed up multiple times a day and encrypted using SSL certificates. See our Privacy Policy for more details.