Reference range:
- ANA stands for "Antinuclear antibodies".
- Antibodies are proteins produced by white blood cells, which normally circulate in the blood to defend against foreign invaders, such as bacteria, viruses, and toxins.
- The antibodies that target “normal” proteins within the nucleus of a cell are called antinuclear antibodies (ANA).
- Most people have antinuclear antibodies, but typically in small amounts. The presence of large amount of autoantibodies or ANAs can indicate an autoimmune disease.
- A negative ANA reading means no antinuclear antibodies are present in the body.
- A positive ANA reading alone does not indicate an autoimmune disease.
ANA IFA is a first line screen for detecting the presence of up to approximately 150 autoantibodies in various autoimmune diseases. A positive ANA IFA result is suggestive of autoimmune disease and reflexes to titer and pattern. Further laboratory testing may be considered if clinically indicated.
Associated Disease: Autoimmune Diseases
Sensitivity: 89% in SLE
ANA has high negative predictive value for ruling out SLE due to its high sensitivity for SLE. However, ANA is found in many autoimmune disorders and a significant proportion of apparently healthy individuals.
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