Alpha-Casein + Beta-Casein

Optimal Result: 0.1 - 1.7 ELISA Index.

Antigen Made From:

Alpha-Casein and Beta-Casein purchased from an antigen supplier.

Associated With:

- Autism

- Autoimmune uveitis

- Celiac disease

- Dairy allergy

Known Cross-Reactions:

A5-B3 glycinin of Soy, Cerebellar, Gliadin,  Retinal-S antigen, anti-Rotavirus IgG, Sheep and Goat milk Casein, Insulin autoantibodies

Clinical Significance:

The presence of antibodies to a-Casein + b-Casein combined is an indication of food immune reactivity. The offending food and its known cross-reactive foods should be eliminated from the diet. Cow’s Milk is the most common cause of food allergy in the first years of life and contributes to maladies such as gastrointestinal upset, skin problems, respiratory manifestations and anaphylaxis. For some the sensitivity persists throughout one’s lifetime and may contribute to autoimmunity later in life. Particular autoimmunities associated with Casein include Celiac disease and autoimmune uveitis. Cow’s Milk plays a role in the gastrointestinal symptoms in 50% of patients with non-celiac gluten sensitivity and Celiac disease.

References:

1. Vojdani et al. Immune response to dietary proteins, gliadin and cerebellar peptides in children with autism. Nutr Neurosci,
2004; 7(3):151-161.

2. Wildner and Diedrichs-Möhring. Autoimmune uveitis induced by molecular mimicry of peptides from rotavirus, bovine casein
and retinal S-antigen. Eur J Immunol, 2003; 33:2577-2587.

3. Cabrera-Chávez et al. Bovine milk caseins and transglutaminase-treated cereal prolamins are differentially recognized by IgA of
celiac disease proteins according to their age. J Agric Food Chem, 2009; 57:3754-3759.

4. Kristjánsson et al. Mucosal reactivity to cow’s milk protein in celiac disease. Clin Exp Immunol, 2007; 147:449-455.

5. Rozenfeld et al. Detection and identification of a soy protein component that cross-reacts with caseins from cow’s milk.
Clin Exp Immunol, 2002; 130:49-58.

6. Schulmeister et al. Cloning, expression, and mapping of allergenic determinants of aS1-casein, a major cow’s milk allergen.
J Immunol, 2009; 182:7019-7029.

7. Vojdani and Tarash. Cross-reaction between gliadin and different food and tissue antigens, Food Nutri Sci, 2013; 4:20-32.

8. Vojdani. Reaction of monoclonal and polyclonal antibodies made against infectious agents with various food antigens. J Clin Cell
Immunol, 2015; 6:359.

9. Spuergin et al. Allergenicity of alpha-caseins from cow, sheep and goat. Allergy, 1997; 52:293-298.

10. Alder et al. Insulin autoantibodies with high affinity to bovine milk protein alpha casein. Clin Exp Immunol, 2001; 164:42-49.

What does it mean if your Alpha-Casein + Beta-Casein result is too high?

The presence of antibodies to a-Casein + b-Casein combined is an indication of food immune reactivity. The offending food and its known cross-reactive foods should be eliminated from the diet. Cow’s Milk is the most common cause of food allergy in the first years of life and contributes to maladies such as gastrointestinal upset, skin problems, respiratory manifestations and anaphylaxis. For some the sensitivity persists throughout one’s lifetime and may contribute to autoimmunity later in life. Particular autoimmunities associated with Casein include Celiac disease and autoimmune uveitis. Cow’s Milk plays a role in the gastrointestinal symptoms in 50% of patients with non-celiac gluten sensitivity and Celiac disease.

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