Mean Corpuscular Haemoglobin Concentration (MCHC)

Complete Blood Count (CBC)

A healthy result should fall into the range 32 - 35 g/dL, 19.90 - 21.77 mmol/L, or 320.00 - 350.00 g/L.

Although closely related, mean corpuscular hemoglobin concentration (MCHC) and mean corpuscular hemoglobin (MCH) are distinct measurements. While MCH represents the average amount of hemoglobin in a single red blood cell, MCHC reflects the hemoglobin concentration in a given unit of packed red blood cells. As with MCV and MCH, calculating the MCHC can help healthcare professionals better assess anemia and other blood disorders.

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What does it mean if your Mean Corpuscular Haemoglobin Concentration (MCHC) result is too low?

Low values are usually accociated with: 

- Acute or chronic bleeding due to menstruation, physical trauma, surgery, or ulcers, for example

- Cancer

- Decreased oxygen availability

- Deficiency in copper or vitamin B6 (pyridoxine)

- Hemolytic anemia

- Iron-deficiency anemia

- Kidney failure

- Lead poisoning

- Removal of the spleen (splenectomy)

- Rheumatoid arthritis

- Sickle cell anemia

- Thalassemia

Low MCHC is not always a cause for concern. Your doctor will evaluate all of your CBC test results in order to make a clear determination about what is causing your abnormal value.

What does it mean if your Mean Corpuscular Haemoglobin Concentration (MCHC) result is too high?

In general, the possible reasons for a high MCHC are consistent with those of high MCV and MCH. However, a type of hereditary hemolytic anemia called spherocytosis has been associated with high MCHC. Anemia caused by a deficiency of vitamin B12 or folic acid is also known to cause high values. Other causes of high MCHC include:

- Alcoholism

- Certain medications, such as anticonvulsant drugs

- Hemolytic anemia

- Hereditary anemia

- Hypothyroidism

- Intestinal disturbances and malabsorption issues

- Liver disease

- Malnutrition

- Megaloblastic anemia

MCHC may also be higher in pregnant women, but values usually return to normal after giving birth.

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