A healthy result should fall into the range 0 - 1.5 µmol/L.
Alpha-aminoadipic acid (α-Aminoadipic acid) is an intermediary metabolite of lysine (primarily) and of tryptophan.
Alpha-aminoadipic acid is elevated in the urine and the most commonly encountered cause is vitamin B6 insufficiency or pyridoxal 5-phosphate dysfunction as a coenzyme for transamination.
Alpha-aminoadipic acid also is a metabolite of yeast/fungi metabolism, and anecdotal evidence supports occasional increases with intestinal dysbiosis as a source.
In Reye’s syndrome, alpha-aminoadipic hyperaminoaciduria occurs together with hyperlysinuria. Rare metabolic and acute alpha-aminoadipic hyperaminoaciduria is documented as due to a hereditary defect in the Alpha-aminoadipic acid transaminase enzyme and in the next enzyme in the sequence, alpha-ketoadipic acid dehydrogenase.
In glutaric acidemia/aciduria there can be notable alpha-aminoadipic hyper-aminoaciduria due to a hereditary weakness of glutaryl CoA dehydrogenase. Riboflavin insufficiency as FAD may provoke or worsen alpha-aminoadipic hyperaminoaciduria (and glutaric acidosis) if the dehydrogenase enzymes are weak, but riboflavin may or may not improve the kinetics of defective dehydrogenases.
If this is high, it’s likely due to a B6 deficiency. B6 is needed by the transaminase enzymes, which convert one amino acid to another, and thus facilitate feeding them into the Krebs cycle. Possible inhibition of lysine metabolism and lowered amine group transfer in the tissues.
Supplement vitamin B6 and α-KG to facilitate the transamination conversion of α-aminoadipic to α-ketoadipic acid.
$15 per monthSelect this plan
$59 per yearSelect this plan
$250 single paymentSelect this plan
Health is not exactly rocket science. You just have to know what your body needs and doesn't need. Your medical tests contain that information. Upload them to our service and we’ll help you understand, organize, and act on them.Get Started
"I was really concerned about my lab results and my GP was not able to see me for another week. Through HealthMatters I was able to interpret my results instantly."
"I've been keeping all my lab results in a spreadsheet, covering approximately 20 years. The HealthMatters team helped me upload that info into the cloud. I can show this data to my family and doctors now easily."
"I had no idea what my lab results meant. Here I found all the biomarkers that I was looking for online. Finally, I have not only organized them all neatly in one place, but I am also grateful to be able to understand what they mean."