Multiple Autoimmune Reactivity Screen (Cyrex Laboratories)

Measures predictive autoantibodies, some of which can appear up to 10 years before clinical symptoms. Efficiently and economically assesses possible tissue damage to multiple organs of the body.

Clinical Use:

- Measure Predictive Antibodies, some of which can appear up to ten years before the clinical onset of disease

- Economically and efficiently assess possible tissue damage to multiple organs of the body

Recommended for Patients Who:

- A diagnosed autoimmune disorder, as they commonly develop additional autoimmune conditions

- Chronic increased intestinal permeability, which is the gateway for environmentally-induced autoimmune disorders

21-Hydroxylase (Adrenal Cortex)

Optimal range: 0.6 - 1.9 ELISA Index

Alpha + Beta Tubulin

Optimal range: 0 - 2.7 ELISA Index

ANTIBODIES ASSOCIATED WITH:
This test by itself is not diagnostic for any condition or disease

Alcoholic Liver Disease
Demyelinating Disease
Graves’ Disease
Hashimoto’s Thyroiditis
Infectious agent exposure
PANDAS / ANDAS / OCD
Rheumatoid Arthritis
Recent Onset Type 1 Diabetes Toxin Exposure

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Alpha-Myosin

Optimal range: 0.6 - 2 ELISA Index

Arthritic Peptide

Optimal range: 0 - 1.7 ELISA Index

ASCA + ANCA

Optimal range: 0.4 - 1.6 ELISA Index

Function:

Saccharomyces cerevisae, baker’s yeast, contains Chl1p, a putative helicase with human homologs (antiSaccharamyces cerevisae antibody – ASCA), which is required for DNA repair, recombination, transcriptional silencing and aging. Anti-neutrophil cytoplasmic antibodies (ANCAs) are a group of autoantibodies against antigens in the cytoplasm of neutrophil granulocytes and monocytes.

Antibodies Appear:

Behçet’s Syndrome with GI Involvement

Crohn’s Disease

Long-term use of Anti-Thyroid Medication

Ulcerative Colitis5 Vasculitis

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Asialoganglioside

Optimal range: 0.6 - 1.6 ELISA Index

GM1 is exposed at the surface of spinal motor neurons, and in the peripheral nerves, it is limited to the node and paranodal region. Low levels of antibodies can be found in normal individuals and in patients with certain autoimmune disorders, however, high titers may be helpful in the diagnosis of multifocal motor neuropathy with conduction block (MMNCB), and paraproteinenia including motor neuron disease and multifocal motor neuropathy.

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Cerebellar

Optimal range: 0.4 - 1.5 ELISA Index

Collagen Complex

Optimal range: 0.2 - 1.5 ELISA Index

Cytochrome P450 (Hepatocyte)

Optimal range: 0.8 - 2.3 ELISA Index

Fibulin

Optimal range: 0.4 - 1.3 ELISA Index

ANTIBODIES ASSOCIATED WITH:
This test by itself is not diagnostic for any condition or disease

Atherosclerotic Lesions
Osteoarthritis  

BODY TISSUE:

Joint

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Glutamic Acid Decarboxylase 65 (GAD 65)

Optimal range: 0.4 - 1.9 ELISA Index

Insulin + Islet Cell Antigen

Optimal range: 0.5 - 1.9 ELISA Index

Intrinsic Factor

Optimal range: 0 - 2.5 ELISA Index

Intrinsic factor is a glycoprotein produced by the parietal cells of the stomach. It is necessary for the absorption of vitamin B12 within distal ileum.

Clinical Significance:

Autoantibodies against Intrinsic Factor are considered highly specific to patients with Pernicious Anemia. Intrinsic Factor antibodies are rarely found in the absence of Pernicious Anemia. Less commonly, Intrinsic Factor antibodies may also be found in patients with Graves’ disease and in relatives of patients with Pernicious Anemia.

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Myelin Basic Protein

Optimal range: 0.6 - 1.7 ELISA Index

Myocardial Peptide

Optimal range: 0 - 1.9 ELISA Index

Osteocyte

Optimal range: 0.7 - 2 ELISA Index

Ovary/Testis

Optimal range: 0.6 - 1.8 ELISA Index

ANTIBODIES ASSOCIATED WITH:
This test by itself is not diagnostic for any condition or disease

Autoimmune Endocrine Disorders
Autoimmune Polyendocrine Syndrome Type 1
Hypogonadism
Premature Menopause
Premature Ovarian Failure

BODY TISSUE:

Reproductive

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Parietal Cell + ATPase

Optimal range: 0 - 2.2 ELISA Index

Phospholipid

Optimal range: 0.4 - 1.7 ELISA Index

Platelet Glycoprotein

Optimal range: 0.6 - 1.8 ELISA Index

ANTIBODIES ASSOCIATED WITH:
This test by itself is not diagnostic for any condition or disease

Arterial Thrombosis
Autoimmune Thrombocytopenia
Cardiovascular Disease
Coronary Artery Disease
Systemic Lupus Erythematosus (SLE)

BODY TISSUE:

Cardiovascular and Endocrine

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Synapsin

Optimal range: 0 - 2.1 ELISA Index

Thyroglobulin

Optimal range: 0.5 - 2 ELISA Index

Thyroid Peroxidase (TPO)

Optimal range: 0 - 2.1 ELISA Index

Tropomyosin

Optimal range: 0 - 3 ELISA Index

Tropomyosin is a cytoskeletal microfilamental protein that regulates actin mechanics. Tropomyosin plays an important role in muscle contraction. Tropomyosin, along with the troponin complex, works with actin in muscle fibers and manages muscle contraction by regulating the binding of myosin. Tropomyosin isoforms are involved in the stabilization of actin filaments, intracellular organelle movement, cell-shape maintenance and cytokinesis.

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