Multiple Autoimmune Reactivity Screen (Cyrex Laboratories)
Measures predictive autoantibodies, some of which can appear up to 10 years before clinical symptoms. Efficiently and economically assesses possible tissue damage to multiple organs of the body.
Clinical Use:
- Measure Predictive Antibodies, some of which can appear up to ten years before the clinical onset of disease
- Economically and efficiently assess possible tissue damage to multiple organs of the body
Recommended for Patients Who:
- A diagnosed autoimmune disorder, as they commonly develop additional autoimmune conditions
- Chronic increased intestinal permeability, which is the gateway for environmentally-induced autoimmune disorders
21-Hydroxylase (Adrenal Cortex)
Optimal range: 0.6 - 1.9 ELISA IndexAlpha + Beta Tubulin
Optimal range: 0 - 2.7 ELISA Index
ANTIBODIES ASSOCIATED WITH:
This test by itself is not diagnostic for any condition or disease
Alcoholic Liver Disease
Demyelinating Disease
Graves’ Disease
Hashimoto’s Thyroiditis
Infectious agent exposure
PANDAS / ANDAS / OCD
Rheumatoid Arthritis
Recent Onset Type 1 Diabetes Toxin Exposure
Alpha-Myosin
Optimal range: 0.6 - 2 ELISA IndexArthritic Peptide
Optimal range: 0 - 1.7 ELISA IndexASCA + ANCA
Optimal range: 0.4 - 1.6 ELISA Index
Function:
Saccharomyces cerevisae, baker’s yeast, contains Chl1p, a putative helicase with human homologs (antiSaccharamyces cerevisae antibody – ASCA), which is required for DNA repair, recombination, transcriptional silencing and aging. Anti-neutrophil cytoplasmic antibodies (ANCAs) are a group of autoantibodies against antigens in the cytoplasm of neutrophil granulocytes and monocytes.
Antibodies Appear:
Behçet’s Syndrome with GI Involvement
Crohn’s Disease
Long-term use of Anti-Thyroid Medication
Ulcerative Colitis5 Vasculitis
LEARN MOREAsialoganglioside
Optimal range: 0.6 - 1.6 ELISA Index
GM1 is exposed at the surface of spinal motor neurons, and in the peripheral nerves, it is limited to the node and paranodal region. Low levels of antibodies can be found in normal individuals and in patients with certain autoimmune disorders, however, high titers may be helpful in the diagnosis of multifocal motor neuropathy with conduction block (MMNCB), and paraproteinenia including motor neuron disease and multifocal motor neuropathy.
LEARN MORECerebellar
Optimal range: 0.4 - 1.5 ELISA IndexCollagen Complex
Optimal range: 0.2 - 1.5 ELISA IndexCytochrome P450 (Hepatocyte)
Optimal range: 0.8 - 2.3 ELISA IndexFibulin
Optimal range: 0.4 - 1.3 ELISA Index
ANTIBODIES ASSOCIATED WITH:
This test by itself is not diagnostic for any condition or disease
Atherosclerotic Lesions
Osteoarthritis
BODY TISSUE:
Joint
LEARN MOREGlutamic Acid Decarboxylase 65 (GAD 65)
Optimal range: 0.4 - 1.9 ELISA IndexInsulin + Islet Cell Antigen
Optimal range: 0.5 - 1.9 ELISA IndexIntrinsic Factor
Optimal range: 0 - 2.5 ELISA Index
Intrinsic factor is a glycoprotein produced by the parietal cells of the stomach. It is necessary for the absorption of vitamin B12 within distal ileum.
Clinical Significance:
Autoantibodies against Intrinsic Factor are considered highly specific to patients with Pernicious Anemia. Intrinsic Factor antibodies are rarely found in the absence of Pernicious Anemia. Less commonly, Intrinsic Factor antibodies may also be found in patients with Graves’ disease and in relatives of patients with Pernicious Anemia.
LEARN MOREMyelin Basic Protein
Optimal range: 0.6 - 1.7 ELISA IndexMyocardial Peptide
Optimal range: 0 - 1.9 ELISA IndexOsteocyte
Optimal range: 0.7 - 2 ELISA IndexOvary/Testis
Optimal range: 0.6 - 1.8 ELISA Index
ANTIBODIES ASSOCIATED WITH:
This test by itself is not diagnostic for any condition or disease
Autoimmune Endocrine Disorders
Autoimmune Polyendocrine Syndrome Type 1
Hypogonadism
Premature Menopause
Premature Ovarian Failure
BODY TISSUE:
Reproductive
LEARN MOREParietal Cell + ATPase
Optimal range: 0 - 2.2 ELISA IndexPhospholipid
Optimal range: 0.4 - 1.7 ELISA IndexPlatelet Glycoprotein
Optimal range: 0.6 - 1.8 ELISA Index
ANTIBODIES ASSOCIATED WITH:
This test by itself is not diagnostic for any condition or disease
Arterial Thrombosis
Autoimmune Thrombocytopenia
Cardiovascular Disease
Coronary Artery Disease
Systemic Lupus Erythematosus (SLE)
BODY TISSUE:
Cardiovascular and Endocrine
LEARN MORESynapsin
Optimal range: 0 - 2.1 ELISA IndexThyroglobulin
Optimal range: 0.5 - 2 ELISA IndexThyroid Peroxidase (TPO)
Optimal range: 0 - 2.1 ELISA IndexTropomyosin
Optimal range: 0 - 3 ELISA Index
Tropomyosin is a cytoskeletal microfilamental protein that regulates actin mechanics. Tropomyosin plays an important role in muscle contraction. Tropomyosin, along with the troponin complex, works with actin in muscle fibers and manages muscle contraction by regulating the binding of myosin. Tropomyosin isoforms are involved in the stabilization of actin filaments, intracellular organelle movement, cell-shape maintenance and cytokinesis.
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